According to their fasting

blood glucose values and initial body weight, diabetic rats were assigned to specific

groups and treated as follows: DN group (tap water, n = 10), A group (ginsenoside

Rb1, weikeqi-biotech, Sichuan, China, 40 mg/kg, n = 10), B group (trigonelline,

weikeqi-biotech, Sichuan, China, 20 mg/kg, n = 10) and the C group (ginsenoside

Rb1 and trigonelline, 60 mg/kg, m (ginsenoside Rb1) : m (trigonelline) = 2:1, n = 10).

The control group was treated as follows: (tap water, n = 10). All rats were gavaged

corresponding drugs or tap water once daily for 12 weeks.