| Product Name | Topotecan |
|---|---|
| CAS | 123948-87-8 |
| Formula | C23H23N3O5 |
| MW | 421.45 |
| Appearance | |
| Boiling point | 782.9±60.0 °C | Condition: Press: 760 Torr |
| PKa | 8.92±0.40 | Condition: Most Acidic Temp: 25 °C |
| Product Name | Topotecan |
|---|---|
| CAS | 123948-87-8 |
| Formula | C23H23N3O5 |
| MW | 421.45 |
| Appearance | |
| Boiling point | 782.9±60.0 °C | Condition: Press: 760 Torr |
| PKa | 8.92±0.40 | Condition: Most Acidic Temp: 25 °C |
| Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer | ||
| Source:SCI：PHARMACOLOGICAL RESEARCH | Author:Yachen Li | Notes：影響因子：5.574 |
| Reference description | ||
TPT and DAI, whose structures are shown in Fig. 1, were both purchased from Sichuan Weikeqi Biological Tech (Chengdu, China). Primary antibodies of Bax, Bcl-2, p53, p21, caspase 9, cleaved-caspase 9, ERα, BCRP and GAPDH were all purchased from Protein Tech (Wuhan, China). | ||
| Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells | ||
| Source:SCI：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | Author:Yongming Bao | Notes：影響因子：3.466 |
| Reference description | ||
PFTα (Fig. 1A) (≥98%), Propidium iodide (PI) and Methyl thiazolyl tetrazolium (MTT) were purchased from Sigma-Aldrich (USA). TPT (Fig. 1B) (≥98%) was purchased from Sichuan Weikeqi Biological Tech (Chengdu, China). DNA Topoisomerase I (Topo I), pBR322, Trizol reagent, reverse transcription kit and real-time quantitative kit were purchased from Takara (Dalian, China). Annexin V-EGFP/PI cell apoptosis kit | ||
