| Product Name | Wilforgine |
|---|---|
| CAS | 37239-47-7 |
| Formula | C41H47NO19 |
| MW | 857.81 |
| Appearance | |
| Melting point | 211 °C |
| Boiling point | 859.9±65.0 °C | Condition: Press: 760 Torr |
| PKa | 11.59±0.70 | Condition: Most Acidic Temp: 25 °C |
| Product Name | Wilforgine |
|---|---|
| CAS | 37239-47-7 |
| Formula | C41H47NO19 |
| MW | 857.81 |
| Appearance | |
| Melting point | 211 °C |
| Boiling point | 859.9±65.0 °C | Condition: Press: 760 Torr |
| PKa | 11.59±0.70 | Condition: Most Acidic Temp: 25 °C |
| Identification and comparison of compounds in commercial Tripterygium wilfordii genus preparations with HPLC-QTOF/MS based on molecular networking and multivariate statistical analysis | ||
| Source:SCI：JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | Author:Ge Xun | Notes：影響因子：3.571 |
| Reference description | ||
Spectra grade methanol and acetonitrile were purchased from Tedia (Fairfeild, USA). HPLC-grade formic acid was purchased from Kermel Chemical Reagent Co., Ltd. (Tianjin, China). Purified water was purchased from Wahaha (Zhejiang, Hangzhou, China). The reference standards triptolide, triptonide, triptophenolide, tripterifordin, wilforgine, wilforine, celastrol, demethylzeylasteral, wilforlide A, and pristimerin were purchased from Sichuan Weikeqi Biological Technology Co., Ltd. (Sichuan, China), and their purity was greater than 98%. Commercial Tripterygium glycosides tablets (TGT) were purchased from 13 factories (A-J), three batches of commercial Tripterygium wilfordii tablets (TWT) were from one factory (K), six different batches of commercial Tripterygium hypoglaucum hutch tablets (THHT) were purchased from two factories (L and M). | ||
| Differences in Multicomponent Pharmacokinetics, Tissue Distribution, and Excretion of Tripterygium Glycosides Tablets in Normal and Adriamycin-Induced Nephrotic Syndrome Rat Models and Correlations With Efficacy and Hepatotoxicity. | ||
| Source:SCI：Frontiers in Pharmacology | Author:Wei Wu | Notes：影響因子：5.988 |
| Reference description | ||
TPL (Lot: 111,567–202,005) and irbesartan (as the IS for the MS/MS determination, Lot: 100,607–201,804) reference substances (content >99%) were obtained from National Institute for Food and Drug Control (Beijing, China). WA (Lot: wkq20040901), WFG (Lot: wkq20040804), WFT (Lot: wkq20040203), WFD (Lot: wkq20040702), and WFR (Lot: wkq20040205) reference substances (content >98%) were purchased from Sichuan Weikeqi Biological Technology Co., Ltd. (Sichuan, China). Adriamycin (ADR) hydrochloride for injection (Lot: 2007E1) was provided by Shenzhen Main Luck Pharmaceuticals Inc. (Shenzhen, China). | ||
| Synchronous Investigation of the Mechanism and Substance Basis of Tripterygium Glycosides Tablets on Anti-rheumatoid Arthritis and Hepatotoxicity | ||
| Source:SCI：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | Author:Qian, Qi | Notes：影響因子：3.094 |
| Reference description | ||
Formic acid was HPLC grade obtained from Fisher (Fair Lawn, NJ, USA). Triptolide (Batch No. wkq18062706, purity?≥?98%), triptonide (Batch No. wkq18030812, purity?≥?98%), triptophenolide (Batch No. wkq18031301), wilforgine (Batch No. wkq18051009, purity?≥?98%), wilforine (Batch No. wkq18080604, purity?≥?98%), demethylzeylasteral (Batch No. wkq18031201, purity?≥?98%), and celastrol (Batch No. wkq18042604, purity?≥?98%) were purchased from Sichuan Weikeqi Biological Technology, Co., Ltd. (Sichuan, P.R. China). | ||
| Wilforine, the Q-marker and PK-maker of Tripterygium glycosides tablet: Based on preparation quantitative analysis and PK-PD study | ||
| Source:SCI：PHYTOMEDICINE | Author:Xue Gao | Notes：影響因子：3.61 |
| Reference description | ||
Wilfortrine (NO. 151128), wilforine (NO. 151218), wilforgine (NO. 150922), and wilfordine (NO. 160127) reference substances (purity? > 98%) were all purchased from Sichuan Weikeqi Biological Technology Co., Ltd., tripterygium glycosides tablet samples were purchased from local pharmaceutical stores (Tianjin, China), which were produced by four manufactures (De-en De (DND) | ||
| Simultaneous determination of seven effective components of Tripterygium glycosides in human biological matrices by ultra performance liquid chromatography–triple quadrupole mass spectrometry | ||
| Source:SCI：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | Author:Xi Du | Notes：影響因子：2.813 |
| Reference description | ||
Triptolide (HPLC purity 99.49%), triptophenolide (HPLC purity 99.29%), celastrol (HPLC purity 98.33%), wilforgine (HPLC purity 99.53%), wilforine (HPLC purity 99.32%) and wilfortrine (HPLC purity 99.09%) were supplied by Weikeqi Biological Technology Co., Ltd (Sichuan, China). Wilfordine (HPLC purity 98%) was purchased from ChemFaces Biochemical Co., Ltd (Wuhan, China) and irbesartan (HPLC purity 99.8%) was used as internal standard (IS) and was obtained from National Institute for Food and Drug Control (Beijing, China). | ||
