| 英文名稱 | Topotecan |
|---|---|
| 中文名稱 | 拓?fù)涮婵?托泊替康/N-甲苯胺鹽酸鹽/甲胺苯鹽酸鹽/(S)-10-[(二甲氨基)甲基]-4-乙基-4,9-二羥基-1H-吡喃并[3',4':6,7]中氮茚并[1,2-B]喹啉-3,14(4H,12H)-二酮/拓?fù)涮婵?d6/2-氮雜二環(huán)[2.1.1]己鹽酸/(1R)-1-(嘧啶-5-基)乙烷-1-胺鹽酸/順-4-氨基四氫吡喃-3-醇鹽酸/拓補(bǔ)替康/帕博西林雜質(zhì)16鹽酸鹽/拓?fù)涮婵蝶}酸鹽水合物 |
| CAS號 | 123948-87-8 |
| 分子式 | C23H23N3O5 |
| 分子量 | 421.45 |
| 外觀 | |
| 沸點 | 782.9±60.0 °C | Condition: Press: 760 Torr |
| 酸度系數(shù)pKa | 8.92±0.40 | Condition: Most Acidic Temp: 25 °C |
WKQ-0001265
中文名稱：拓?fù)涮婵?/p>
中文別稱：托泊替康；N-甲苯胺鹽酸鹽；甲胺苯鹽酸鹽；(S)-10-[(二甲氨基)甲基]-4-乙基-4,9-二羥基-1H-吡喃并[3',4':6,7]中氮茚并[1,2-B]喹啉-3,14(4H,12H)-二酮；拓?fù)涮婵?d6；2-氮雜二環(huán)[2.1.1]己鹽酸；(1R)-1-(嘧啶-5-基)乙烷-1-胺鹽酸；順-4-氨基四氫吡喃-3-醇鹽酸；拓補(bǔ)替康；帕博西林雜質(zhì)16鹽酸鹽
英文名稱：Topotecan
英文別名：1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-;(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(19S)-8-[(Dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione;(S)-Topotecan;10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin;9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin;Evotopin;Hycamptamine;Hycamptin;NSC 609699;Nogitecan;Potactasol;SKF 104864;SKF-S 104864;TopoCED;Topophore C;Topotecan;Topotecan lactone;ZINC 1611274;
分子式：C23H23N3O5
分子量：421.45
CAS號：123948-87-8
純度：HPLC≥98%
沸點：782.9±60.0 °C | Condition: Press: 760 Torr
密度：1.49±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
酸系度數(shù)：8.92±0.40 | Condition: Most Acidic Temp: 25 °C
儲存條件：-20℃，干燥、避光、密封
規(guī)格：5mg10mg20mg50mg100mg500mg1g2g等應(yīng)客戶需求包裝
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| Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer | ||
| 來源：SCI：PHARMACOLOGICAL RESEARCH | 作者：Yachen Li | 備注：影響因子：5.574 |
| 引用描述 | ||
TPT and DAI, whose structures are shown in Fig. 1, were both purchased from Sichuan Weikeqi Biological Tech (Chengdu, China). Primary antibodies of Bax, Bcl-2, p53, p21, caspase 9, cleaved-caspase 9, ERα, BCRP and GAPDH were all purchased from Protein Tech (Wuhan, China). | ||
| Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells | ||
| 來源：SCI：EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 作者：Yongming Bao | 備注：影響因子：3.466 |
| 引用描述 | ||
PFTα (Fig. 1A) (≥98%), Propidium iodide (PI) and Methyl thiazolyl tetrazolium (MTT) were purchased from Sigma-Aldrich (USA). TPT (Fig. 1B) (≥98%) was purchased from Sichuan Weikeqi Biological Tech (Chengdu, China). DNA Topoisomerase I (Topo I), pBR322, Trizol reagent, reverse transcription kit and real-time quantitative kit were purchased from Takara (Dalian, China). Annexin V-EGFP/PI cell apoptosis kit | ||
